Bupropion is an antidepressant medication approved for the treatment of major depressive disorder and seasonal affective disorder (SAD). Wellbutrin and Alcohol are both central nervous system-active (CNS-active) compounds and combining them can possibly lead to unwanted effects. With almost any medicine someone takes, there can be things to ensure you’re aware of, and also interactions and side effects of mixing it with other substances. Bupropion, sold under the brand names Wellbutrin and Zyban among others, is a medication primarily used to treat major depressive disorder and to support stopping smoking. It is an effective antidepressant on its own, but is also used as an add-on medication in cases of incomplete response to first-line SSRI antidepressants. Find patient medical information for Wellbutrin XL Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. The Wellbutrin brand name has been discontinued in the U.S. If generic versions of this product have been approved by the FDA, there may be generic equivalents available. Learn about the potential side effects of Wellbutrin (bupropion). Includes common and rare side effects information for consumers and healthcare professionals. DESCRIPTION. WELLBUTRIN SR (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents. Sexual side effects are common with antidepressants in both men and women, but there are options to prevent or reduce such side effects. DESCRIPTION. WELLBUTRIN (bupropion hydrochloride), an antidepressant of the aminoketone class, is chemically unrelated to tricyclic, tetracyclic, selective serotonin re-uptake inhibitor, or other known antidepressant agents.